Welcome to the Yang Lab!

The research in our lab is focused on the structure, dynamics, and function of nuclear hormone receptors by employing an innovative integration of biophysical computations and X-ray scattering techniques. Our research efforts benefit from the excellent computing facilities and synchrotron sources to which we have access, and close links with other laboratories here at Cleveland and other parts of the nation.

Recent News:

May 2013: The work on simulating and predicting the protein domain interactions in estrogen receptor is accepted for publication.
Feb. 2013: The Fast-SAXS-pro webserver is up and running! Software download is available as well.
December 2012: The work on developing the software of Fast-SAXS-pro, a simple and fast method to computing SAXS profiles of biomolecules, is accepted for publication.
August 2012: Research featured on the Cover!

Picture: Energy landscape of protein-protein interactions on a three-dimensional globe. The globe provides an overview of the landscape by specifying the relative orientations and interaction energies of the two proteins: one is at the center of the globe (in yellow) and the other is on the surface. The globe is colored and plotted with contour lines based on the interaction energies of a large set of simulated orientations. Three distinct orientations are illustrated for the second protein in red, green, and orange, respectively, each located in an energy basin on the surface. This energy globe is intuitive in outlining energetically favorable complex-forming conformations from a landscape perspective.
August 2012: The collaborative work on nuclear receptor function is published at J. Biol. Chem.
July 2012: The work on "simulating protein-protein interactions" is accepted for publication.
June 2012: The study on the assembly of multidomain proteins received another hightlight from Nature Chemical Biology, nearly two years after its publication. See a Commentary by Peter Tompa.
May 2012: Awarded a CTSC pilot grant.
August 31, 2011: A webserver for scattering calculation is available using Fast-SAXS.
April 1, 2011: S.Y. and his long-term collaborator have been awarded by the Department of Defense.
Feb 1, 2011: Our report on coarse-grained simulations of conformational transition/disorder is ranked 1st in views/downloads at PLoS Computational Biology since launch. See a statistical Table published in a recent PLoS Editorial article.
Dec 23, 2010: We are pleased to learn that the SAXS work is featured in Nature for coverage. See a nice News & Views article by Bernadó and Blackledge.
September 1, 2010: S.Y. was awarded with an American Cancer Society (ACS/CCCC) Pilot grant.
July 14, 2010: We start the wet-lab planning.
July 12, 2010: Our computer/cluster lab is in production.
July 1, 2010: Our new lab starts. And welcome!