Welcome to the Yang Lab!
webserver of SAXS computing: fast-SAXS-pro
Our research is focused on developing innovative methods for basic and translational studies of estrogen receptor (ER), a key target of breast cancer therapeutics. We have developed integrated structure modeling–that combines multiple-level synchrotron biophysics data via computational sampling–and applied to ER for discovering new signaling pathways between hormone and DNA binding. We are excited in translating this new knowledge to elucidate notorious resistance of antiestrogen therapy and to pursuit drug discovery of advanced breast cancer. Equally important is developing data-driven computational models and algorithms that will enable novel approaches to study protein folding, dynamics, and function in solution. Our research efforts benefit from excellent computing facilities and synchrotron sources to which we have access, and close links with other laboratories here at Cleveland and other parts of the nation.